Hydrochloric Acid → HCID 20380013, compound

Participants

Reaction Steps

A mixture of 3 g (0.0065 mole) of 4'-dimethylamino-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone hydrochloride, 150 ml of ethanol and 150 ml of 37% HCl was heated on a steam bath about 4 hours. The solvent and excess acid were removed. The remaining solid was recrystallized from methanol-butanone, converted to the free base, and recrystallized for benzene-hexane to give the desired product, M.P. 110°-112° C.

Provenance & Evidence