Hydrochloric Acid → HCID 20380013, compound

HRID 1448503Notes

Reaction equation

HRID 1448503 reaction equation
Cl.[CH3:2][N:3]([CH3:35])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20](O)([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:16][CH2:15]2)=[CH:6][CH:5]=1.Cl>C(O)C>[CH3:35][N:3]([CH3:2])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17](=[C:20]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:16][CH2:15]2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20379980HCID 20379980, compound

Product 1

HCID 20380013HCID 20380013, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3 g (0.0065 mole) of 4'-dimethylamino-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone hydrochloride, 150 ml of ethanol and 150 ml of 37% HCl was heated on a steam bath about 4 hours. The solvent and excess acid were removed. The remaining solid was recrystallized from methanol-butanone, converted to the free base, and recrystallized for benzene-hexane to give the desired product, M.P. 110°-112° C.

Workup

  1. temperaturewas heated on a steam bath about 4 hours
  2. customThe solvent and excess acid were removed
  3. customThe remaining solid was recrystallized from methanol-butanone
  4. customrecrystallized for benzene-hexane

Sources & evidence

ORD record
ord-5c959916e3684e28bbdd6aa9a09cd3b9
Source dataset
uspto-grants-1979_12
Patent number
US04180583

Reaction notes

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