2-ethoxy-9-methoxy-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one → 8-Methoxypsoralen

HRID 1448512Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1448512
C(O[CH:4]1[O:19][C:7]2=[C:8]([O:17][CH3:18])[C:9]3[O:14][C:13](=[O:15])[CH:12]=[CH:11][C:10]=3[CH:16]=[C:6]2[CH2:5]1)C>C(O)=O>[CH3:18][O:17][C:8]1[C:9]2[O:14][C:13](=[O:15])[CH:12]=[CH:11][C:10]=2[CH:16]=[C:6]2[CH:5]=[CH:4][O:19][C:7]=12

Komponenten

3

Edukt 1

HCID 203802252-ethoxy-9-methoxy-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one

Produkt 1

HCID 41148-Methoxypsoralen

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

A solution of 100 mg. (0.38 mmole) of 2-ethoxy-9-methoxy-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one in 2 ml. of formic acid was heated at 100° for 30 min. The reaction was cooled and evaporated to leave a residue which was filtered through alumina using benzene/ethyl acetate, 4:1 to yield, upon evaporation of the filtrate, pure 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one, mp 145°-146°.

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. customevaporated
  3. customto leave a residue which
  4. filtrationwas filtered through alumina

Quellen und Nachweise

ORD-Eintrag
ord-68e5aff5acda40dc9205d28c5fcdb61c
Quelldatensatz
uspto-grants-1979_12
Patentnummer
US04180659

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