Hydrochloric Acid → HCID 178465550, compound

HRID 1448615Notes

Reaction equation

HRID 1448615 reaction equation
C([NH:4][CH:5]([N:7]1[C:11]([SH:12])=[N:10][N:9]=[N:8]1)[CH3:6])(=O)C.[ClH:13]>>[ClH:13].[NH2:4][CH:5]([N:7]1[C:11]([SH:12])=[N:10][N:9]=[N:8]1)[CH3:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178474868HCID 178474868, compound

Product 1

HCID 178465550HCID 178465550, compoundYield 77%

Procedure

A mixture of 61.3 g. (0.3274 M.) 1-acetamidoethyl-5-mercaptotetrazole and 313 ml. 6 N HCl (196 mg./ml.; 1.888 M.) was heated at reflux for 2 hours. The resulting solution was treated with 10 g. carbon and evaporated at 45° C. (15 mm.) to a solid which was triturated with 90 ml. glacial acetic acid, washed with 250 ml. ether and dried in vacuo over P2O5 to give 45.6 g. (77% yield) of 1-aminoethyl-5-mercaptotetrazole hydrochloride.

Workup

  1. additionA mixture of 61.3 g
  2. temperatureat reflux for 2 hours
  3. additionThe resulting solution was treated with 10 g
  4. customcarbon and evaporated at 45° C. (15 mm.) to a solid which
  5. customwas triturated with 90 ml
  6. washglacial acetic acid, washed with 250 ml
  7. dry with materialether and dried in vacuo over P2O5
  8. customto give 45.6 g

Sources & evidence

ORD record
ord-2c8be0103d9b4ef687da0a31ff644ce8
Source dataset
uspto-grants-1979_12
Patent number
US04180658

Reaction notes

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