1-Propanol → HCID 86736385, compound

HRID 1448687Notes

Reaction equation

HRID 1448687 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14](Cl)=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1.[CH2:19]([OH:22])[CH2:20][CH3:21]>>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14]([O:22][CH2:19][CH2:20][CH3:21])=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 10311-PropanolHCID 23465058HCID 23465058, compound

Product 1

HCID 86736385HCID 86736385, compoundYield 100.5%

Procedure

A solution of 2.92 g (0.010 mol) of 3-(α,α,α-trifluoro-m-tolyl)-4-isothiazolecarbonyl chloride and 4 g (0.0667 mol) of 1-propanol was heated on a steam bath for 1 hour and was concentrated under vacuum to 70° (0.5 torr) to give 3.17 g of clear oil, nD20.8 =1.5261, infrared (film) 5.80μ.

Workup

  1. concentrationwas concentrated under vacuum to 70° (0.5 torr)

Sources & evidence

ORD record
ord-cb2d4a4d2ab8439abfd9bd286244f2cb
Source dataset
uspto-grants-1980_02
Patent number
US04187099

Reaction notes

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