Ethylene Glycol → 3-Hydroxy-2,6-dimethyl-4-(1,1,3,3-tetramethylbutyl)benzeneacetic acid

HRID 1448769Notes

Reaction equation

HRID 1448769 reaction equation
[C:1]([C:9]1[CH:14]=[C:13]([CH3:15])[C:12](CC#N)=[C:11]([CH3:19])[C:10]=1[OH:20])([CH2:4][C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:3])[CH3:2].[OH-:21].[Na+].[CH2:23]([OH:26])[CH2:24]O>>[C:1]([C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([CH2:24][C:23]([OH:26])=[O:21])=[C:11]([CH3:19])[C:10]=1[OH:20])([CH2:4][C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 174Ethylene GlycolHCID 14798Sodium HydroxideHCID 86734106HCID 86734106, compound

Product 1

HCID 867341053-Hydroxy-2,6-dimethyl-4-(1,1,3,3-tetramethylbutyl)benzeneacetic acid

Procedure

This compound was made in a similar manner to the method disclosed in Example 5 by hydrolyzing 4-tert.-octyl-2,6-dimethyl-3-hydroxyphenylacetonitrile with sodium hydroxide in aqueous ethylene glycol. After crystallization from toluene 4-tert.-octyl-2,6-dimethyl-3-hydroxyphenylacetic acid melted at 157° to 159° C.

Workup

  1. customAfter crystallization from toluene 4-tert.-octyl-2,6-dimethyl-3-hydroxyphenylacetic acid melted at 157° to 159° C.

Sources & evidence

ORD record
ord-e852a8053ed84628a629f65553abd6db
Source dataset
uspto-grants-1980_02
Patent number
US04187246

Reaction notes

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