Methylamine → HCID 12377125, compound

HRID 1448804Notes

Reaction equation

HRID 1448804 reaction equation
Cl[CH2:2][C:3]1[N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([O:21]C)=O)[C:11](=[O:23])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[CH3:24][NH2:25]>COCCO>[CH3:24][N:25]1[C:11](=[O:23])[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]2[C:19](=[O:21])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[N:12]=[C:3]2[CH2:2]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20375579HCID 20375579, compound

Product 1

HCID 12377125HCID 12377125, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

16.4 g (0.05 mol) of 2-chloromethyl-3-(2-methoxycarbonyl-phenyl)-4H-quinazolin-4-one and 10 ml of liquid methylamine in 100 ml of ethylene glycol monomethyl ether are heated to 40° C. for 2 hours in an autoclave. After cooling the mixture, the colourless crystals are filtered off and washed several times with ethanol. 12 g (82.5% of theory) of 6-methyl-6,7-dihydro-5H,13H-quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione are obtained.

Workup

  1. temperatureAfter cooling the mixture
  2. filtrationthe colourless crystals are filtered off
  3. washwashed several times with ethanol

Sources & evidence

ORD record
ord-2158a267f63a4c39833b1fea31455c31
Source dataset
uspto-grants-1980_02
Patent number
US04187306

Reaction notes

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