Phenethylamine → HCID 20375600, compound

HRID 1448805Notes

Reaction equation

HRID 1448805 reaction equation
Cl[CH2:2][C:3]1[N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19](OC)=[O:20])[C:11](=[O:23])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[C:24]1([CH2:30][CH2:31][NH2:32])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>COCCO>[C:24]1([CH2:30][CH2:31][N:32]2[C:19](=[O:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[N:12]3[C:11](=[O:23])[C:10]4[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=4[N:4]=[C:3]3[CH2:2]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 20375579HCID 20375579, compound

Product 1

HCID 20375600HCID 20375600, compoundYield 30.5%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

16.4 g (0.05 mol) of 2-chloromethyl-3-(2-methoxycarbonyl-phenyl)-4H-quinazolin-4-one and 12.1 g (0.1 mol) of 2-phenylethylamine in 100 ml of ethylene glycol monomethyl ether are heated to 100° C. for 5 hours. The solvent is evaporated off on a Rotavapor and 100 ml of water are added to the semi-solid residue. The colourless crystals are filtered off and washed with hot methanol. 5.8 g (30.5% of theory) of 6-(2-phenylethyl)-6,7-dihydro-5H,13H-quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione are obtained.

Workup

  1. customThe solvent is evaporated off on a Rotavapor and 100 ml of water
  2. additionare added to the semi-solid residue
  3. filtrationThe colourless crystals are filtered off
  4. washwashed with hot methanol

Sources & evidence

ORD record
ord-f49413faca0848bcac4bb4a510ff4e63
Source dataset
uspto-grants-1980_02
Patent number
US04187306

Reaction notes

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