反应详情

A solution of 190 mg (1 m mole) of methyl 3-amino-1,5-cyclohexadienecarboxylate hydrochloride in 5 ml of dichloromethane is treated with 78 mg (1 m mole) of acetyl chloride and 202 mg (2 m mole) of triethylamine for 1 hour at 25° C. after which the solution is washed with water, dryed and concentrated. The residue is treated at 25° C. with 3 ml of methanol and 100 ml of sodium hydroxide in 200 ml of water for 3 hours then acidified and extracted with dichloromethane. The organic phase is dried and evaporated to afford 3-acetamido-1,5-cyclohexadiene carboxylic acid.

1. washis washed with water
2. concentrationconcentrated
3. additionThe residue is treated at 25° C. with 3 ml of methanol and 100 ml of sodium hydroxide in 200 ml of water for 3 hours
4. extractionextracted with dichloromethane
5. customThe organic phase is dried
6. customevaporated