Boc-L-Valine → HCID 91979019, compound

HRID 1448864Notes

Reaction equation

HRID 1448864 reaction equation
[NH:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:2]([C:6]([OH:8])=O)[CH:3]([CH3:5])[CH3:4].[NH:16]1[CH2:28][CH2:27][CH2:26][C@H:17]1[C:18]([NH:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])=[O:19].Cl>>[NH:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:2]([C:6]([N:16]1[CH2:28][CH2:27][CH2:26][C@H:17]1[C:18]([NH:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])=[O:19])=[O:8])[CH:3]([CH3:4])[CH3:5]

Participants

3

Reactant 2

HCID 83693Boc-L-ValineHCID 1327316134290-71-6

Product 1

HCID 91979019HCID 91979019, compound

Procedure

Boc-Val-OH (52.1 g, 240 mmol) was reacted with II (53.4 g, 240 mmol) by the mixed anhydride method as described for the preparation of I in part (a). The resulting oil showed a single spot on TLC; yield 64.0 g (69%), Rf1 0.69.

Sources & evidence

ORD record
ord-3c20e92bf6a14814a14372a85c123524
Source dataset
uspto-grants-1980_02
Patent number
US04187852

Reaction notes

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