1-(3-hydroxy-1-phenyl-1H-indol-2-yl)-2-(methylsulfonyl)ethanone → 3-Hydroxy-1-phenyl-1H-indol-2-yl methyl ketone

HRID 1448890Notes

Reaction equation

HRID 1448890 reaction equation
[OH:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]=1[C:17](=[O:23])[CH2:18]S(C)(=O)=O.C(O)C.C(O)(=O)C>O>[CH3:18][C:17]([C:3]1[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]2[C:10]([C:2]=1[OH:1])=[CH:9][CH:8]=[CH:7][CH:6]=2)=[O:23]

Participants

4

Reactant 2

HCID 125113191-(3-hydroxy-1-phenyl-1H-indol-2-yl)-2-(methylsulfonyl)ethanoneHCID 18476134Acetic acid ethanol

Product 1

HCID 125113213-Hydroxy-1-phenyl-1H-indol-2-yl methyl ketone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a manner analogous to that of Example 5, the title compound was prepared from 1-(3-hydroxy-1-phenyl-1H-indol-2-yl)-2-(methylsulfonyl)ethanone. The product was obtained as green needles of mpt. 127°-130° from the condensed ethanol-acetic acid filtrate by the addition of warm water, followed by slow cooling.

Workup

  1. customThe product was obtained as green needles of mpt

Sources & evidence

ORD record
ord-ff8ecc3676cd48da8a8ddebc90ae7b87
Source dataset
uspto-grants-1980_02
Patent number
US04188326

Reaction notes

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