Benzene → 2,6-Dimethylaniline

12.9 g (0.23 mole) of freshly distilled acrolein is added dropwise at room temperature to a solution of 27.8 g (0.2 mole) of N-(3-pent-2-enyl)-pyrrolidine in 50 ml of absolute benzene, with the temperature rising to a maximum of 50° C. After completion of the addition, the mixture is stirred for 2 hours at room temperature. It is subsequently boiled for 15 hours at about 110° C. bath temperature in a water-separator. The oil obtained after evaporating off the solvent is heated for 18 hours with 100 ml of abs. dioxane, 10.0 g of ammonia, 50.0 g of propylene and 5.0 g of palladium on charcoal (5%) at 120°-130° C. under a pressure of 47 bars (nitrogen). After the addition of 100 ml of ether, the catalyst is filtered off and washed three times with ether. The oil obtained after removal of the solvent by evaporation is distilled in vacuo. There is obtained 4.5 g (20% of theory) of 2,6-dimethylaniline, b.p. 103° C./ 18 Torr, and as byproducts 1.9 g (8% of theory) of 2,6-dimethyl-cyclohex-2-en-1-one, b.p. 62°-64° C./ 17 Torr, and 2.4 g (10% of theory) of 2,6-dimethyl-cyclohexanone.

1. customrising to a maximum of 50° C
2. additionAfter completion of the addition
3. waitIt is subsequently boiled for 15 hours at about 110° C.
4. customThe oil obtained
5. customafter evaporating off the solvent
6. temperatureis heated for 18 hours with 100 ml of abs
7. customat 120°-130° C.
8. additionAfter the addition of 100 ml of ether
9. filtrationthe catalyst is filtered off
10. washwashed three times with ether
11. customThe oil obtained
12. customafter removal of the solvent
13. customby evaporation
14. distillationis distilled in vacuo

ORD record

ord-11f3eefd9c3b41459d6f8eecb7eb342d

Source dataset

uspto-grants-1980_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04188341