Chloroform → 2,6-Dimethylaniline

Temperature

25 °C

14.0 g (0.25 mol) of acrolein is added dropwise at maximal temperature of 40° C. to a solution of 23.3 g (0.15 mol) of N-(2-penten-2-yl)-morpholine in 100 ml of abs. chloroform. The mixture is stirred for 15 hours at 25° C. and then for further 15 hours at 50° C. Thereafter the solvent is distilled off and the residue is transferred into an autoclave and, after addition of 400 ml concentrated aqueous ammonia and 10.0 g of paladium coal (5%) the whole is heated under a nitrogen pressure of 50 bar for 15 hours at 280° to 290° C. Subsequently the catalyst is separated by filtration and washed with ether. After separation of the etheral layer the filtrate is several times extracted with ether. The extracts are combined and dried over magnesium sulphate and the ether is distilled off. The residue (22 g) is distilled in vacuo. There is obtained 6.5 g (35% of theory) of 2,6-dimethylaniline, b.p. 15 : 94°-96° C.

1. waitfor further 15 hours at 50° C
2. distillationThereafter the solvent is distilled off
3. additionafter addition of 400 ml concentrated aqueous ammonia and 10.0 g of paladium coal (5%) the whole
4. temperatureis heated under a nitrogen pressure of 50 bar for 15 hours at 280° to 290° C
5. customSubsequently the catalyst is separated by filtration
6. washwashed with ether
7. customAfter separation of the etheral layer the filtrate
8. extractionextracted with ether
9. dry with materialdried over magnesium sulphate
10. distillationthe ether is distilled off
11. distillationThe residue (22 g) is distilled in vacuo

ORD record

ord-e7dcd794c7e148a89e68414d87dc727e

Source dataset

uspto-grants-1980_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04188341