HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenol → 3-chloro-6-(4-chlorophenoxy)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3,6-Dichloropyridazine | HCID 67331 | — |
| Product | 3-chloro-6-(4-chlorophenoxy)pyridazine | HCID 10752591 | 70% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of 14.9 g 3,6-dichloro-pyridazine, 10.45 g 4-chlorophenol and 13.8 g potassium carbonate is maintained for half an hour at 160° C., and then poured into an aqueous dilute sodium hydroxide solution. The precipitate which appears in isolated and recrystallised from an aromatic solvent. There is thus obtained, at 70% yield, 3-chloro-6-(4-chlorophenoxy)-pyridazine which melts at 119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04188388 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-755aaf1437f04152b4bfad76b242c51d |
| Source note | uspto-grants-1980_02 |