2-Chloroethanol → 3(2H)-Pyridazinone, 6-(2-chlorophenoxy)-2-(2-hydroxyethyl)-

Participants

Reaction Conditions

Reaction Steps

2.4 g sodium are dissolved in 100 ml anhydrous 1-butanol and then 30 g 6-(2-chlorophenoxy)-3-pyridazinone prepared in a manner analogous to Example 1 (M.Pt=182° C.) and the reaction mixture is maintained at 100° C. for 1 hour. 9 g 2-chloroethanol are then introduced without application of heat and then the mixture maintained for 9 hours at reflux temperature. The solvent is removed under reduced pressure, 50 ml aqueous N-sodium hydroxide solution are poured onto the residue and the final product is extracted in diethyl ether.

Provenance & Evidence