Sodium ethoxide → HCID 10848647, compound

HRID 1448989Notes

Reaction equation

HRID 1448989 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=S)[NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[O-]CC.[Na+]>C(O)C>[F:19][C:16]1[CH:15]=[CH:14][C:13]([C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 13508053HCID 13508053, compound

Product 1

HCID 10848647HCID 10848647, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4,5-bis(4-fluorophenyl)-1H-imidazole-2-thione (8.0 g, 0.028 mol), sodium ethoxide (1.9 g, 0.028 mol) and 1,2-diiodotetrafluoroethylene (4.9 g, 0.014 mol) in ethanol (100 ml) was refluxed for two hours and then cooled. The yellow precipitate was collected, washed with ethanol and recrystallized from chloroform to give the title compound, m.p. 234°-236°.

Workup

  1. temperaturewas refluxed for two hours
  2. temperaturecooled
  3. customThe yellow precipitate was collected
  4. washwashed with ethanol
  5. customrecrystallized from chloroform

Sources & evidence

ORD record
ord-06f309a4e3a945e1a09d0e339becba3e
Source dataset
uspto-grants-1980_02
Patent number
US04188397

Reaction notes

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