Iodine → HCID 20374817, compound

HRID 1448991Notes

Reaction equation

HRID 1448991 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][C:11](=[S:22])[NH:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=2)=[CH:5][CH:4]=1.[O-][CH2:24][CH3:25].[Na+].II>C(O)C>[S:22]([C:11]1[NH:12][C:13]([C:25]2[CH:24]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=2)=[C:9]([C:6]2[CH:5]=[CH:4][C:3]([S:2][CH3:1])=[CH:8][CH:7]=2)[N:10]=1)[C:11]1[NH:10][C:9]([C:6]2[CH:5]=[CH:4][C:3]([S:2][CH3:1])=[CH:8][CH:7]=2)=[C:13]([C:14]2[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=2)[N:12]=1

Participants

5

Reactant 3

HCID 807IodineHCID 2723922Sodium ethoxideHCID 13526416HCID 13526416, compound

Product 1

HCID 20374817HCID 20374817, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4,5-bis(4-methylthiophenyl)-1H-imidazole-2-thione (5.2 g, 0.015 mol), sodium ethoxide (1.0 g, 0.015 mol) and iodine (1.9 g, 0.0075 mol) in ethanol (70 ml) was stirred at ambient temperature for three hours. The resulting solid was collected, washed with ethanol and then ether. Recrystallization from N,N-dimethylformamide give the title compound, m.p. 297°-298°.

Workup

  1. customThe resulting solid was collected
  2. washwashed with ethanol
  3. customRecrystallization from N,N-dimethylformamide

Sources & evidence

ORD record
ord-cd09ca7b091442fca1e841e62ed2dee5
Source dataset
uspto-grants-1980_02
Patent number
US04188397

Reaction notes

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