反应详情

7,8-Diamino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one (43 mg, 0.13 mmol) is dissolved in formic acid (1.5 ml), and the solution is heated at reflux for 1 h. The reaction mixture is cooled to room temperature, diluted with ethyl acetate (40 ml) and washed with saturated sodium bicarbonate solution (2×30 ml), water (40 ml) and saturated brine (30 ml). The organic layer is dried (MgSO4), filtered and evaporated to give a pale yellow solid. This is triturated with n-hexane/ethyl acetate/dichloromethane and filtered to give a colourless powder.

1. temperaturethe solution is heated
2. temperatureat reflux for 1 h
3. washwashed with saturated sodium bicarbonate solution (2×30 ml), water (40 ml) and saturated brine (30 ml)
4. dry with materialThe organic layer is dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customto give a pale yellow solid
8. customThis is triturated with n-hexane/ethyl acetate/dichloromethane
9. filtrationfiltered
10. customto give a colourless powder