HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinecarboxaldehyde → 2-Acetoxymethyl-6-methyl-4-(-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinecarboxaldehyde | HCID 14273 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-acetoxyacetoacetate | HCID 11480907 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Acetoxymethyl-6-methyl-4-(-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70590562 | 60% |
Reaction Steps
A solution of 5.4 g of pyridine-2-aldehyde, 9.4 g of γ-acetoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol is heated to the boil overnight and then cooled. After filtering, beige crystals of melting point 116° C. are obtained, yield: 60%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04188395 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-e08fa508130a4167ad5f7b53459c2441 |
| Source note | uspto-grants-1980_02 |