Benzaldehyde → HCID 70588723, compound

HRID 1449004Notes

Reaction equation

HRID 1449004 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:9]([O:11][C:12](=[O:21])[CH2:13][C:14]([CH2:16][O:17][C:18](=[O:20])[CH3:19])=O)[CH3:10].[CH2:22]([O:24][C:25](=[O:30])/[CH:26]=[C:27](\[NH2:29])/[CH3:28])[CH3:23]>O1CCOCC1>[CH2:9]([O:11][C:12]([C:13]1[CH:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:26]([C:25]([O:24][CH2:22][CH3:23])=[O:30])=[C:27]([CH3:28])[NH:29][C:14]=1[CH2:16][O:17][C:18](=[O:20])[CH3:19])=[O:21])[CH3:10]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 11480907Ethyl 4-acetoxyacetoacetate

Product 1

HCID 70588723HCID 70588723, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 5 g of benzaldehyde, 9.4 g of γ-acetoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 50 ccs of dioxane is heated to the boil overnight and then cooled. After filtering, light yellow crystals of melting point 104°-106° C. are obtained, yield: 50%.

Workup

  1. temperaturecooled
  2. filtrationAfter filtering
  3. customlight yellow crystals of melting point 104°-106° C. are obtained

Sources & evidence

ORD record
ord-71cce98c00734aec8f6e54ea5be9cde4
Source dataset
uspto-grants-1980_02
Patent number
US04188395

Reaction notes

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