2-Chlorobenzaldehyde → HCID 13388343, compound

HRID 1449006Notes

Reaction equation

HRID 1449006 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:10]([O:12][C:13](=[O:22])[CH2:14][C:15]([CH2:17][O:18][C:19](=[O:21])[CH3:20])=O)[CH3:11].[CH2:23]([O:25][C:26](=[O:31])/[CH:27]=[C:28](\[NH2:30])/[CH3:29])[CH3:24]>C(O)C>[CH2:10]([O:12][C:13]([C:14]1[CH:4]([C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[Cl:1])[C:27]([C:26]([O:25][CH2:23][CH3:24])=[O:31])=[C:28]([CH3:29])[NH:30][C:15]=1[CH2:17][O:18][C:19](=[O:21])[CH3:20])=[O:22])[CH3:11]

Participants

5

Reactant 3

HCID 69962-ChlorobenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 11480907Ethyl 4-acetoxyacetoacetate

Product 1

HCID 13388343HCID 13388343, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7 g of 2-chlorobenzaldehyde, 9.4 g of γ-acetoxy-acetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol are heated under reflux overnight and cooled and light yellow crystals of melting point 102° C. are obtained, yield: 40%.

Workup

  1. temperatureunder reflux overnight
  2. temperaturecooled
  3. customlight yellow crystals of melting point 102° C. are obtained

Sources & evidence

ORD record
ord-a2485e5718904e35b2ab9a8a5e503e6e
Source dataset
uspto-grants-1980_02
Patent number
US04188395

Reaction notes

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