反应详情

28 g of 2-chlorobenzaldehyde, 56 g of phthalimidoacetoacetic acid ethyl ester and 25.8 g of β-aminocrotonic acid ethyl ester in 250 ccs of ethanol are heated to the boil under reflux for about 70 hours, the mixture is allowed to cool, whilst stirring, and, after filtering, light yellow crystals of melting point 166° C. are obtained, yield: 50%.

1. temperatureunder reflux for about 70 hours
2. temperatureto cool
3. filtrationafter filtering
4. customlight yellow crystals of melting point 166° C. are obtained