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HRID1449019

反应详情

EQUATION

反应方程式

HRID 1449019 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1ccccc1Cl
HCID6996

2-Chlorobenzaldehyde

C7H5ClO

结构：CCOC(=O)/C=C(/C)N
HCID643756

未命名化合物

结构：CCOC(=O)CC(=O)CN1C(=O)c2ccccc2C1=O
HCID701239

Ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoate

C14H13NO5

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(C)NC(CN2C(=O)c3ccccc3C2=O)=C(C(=O)OCC)C1c1ccccc1Cl
HCID70591937

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

13 g of 2-chlorobenzaldehyde, 28 g of phthalimidoacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 250 ccs of ethanol are heated to the boil under reflux for about 70 hours, the mixture is allowed to cool, whilst stirring, and after filtering, light yellow crystals of melting point 174°-176° C. are obtained; yield: 90%.

WORKUP

后处理

  1. temperatureunder reflux for about 70 hours
  2. temperatureto cool
  3. filtrationafter filtering
  4. customlight yellow crystals of melting point 174°-176° C. are obtained