反应详情

To a stirred solution of 24 parts of diphenylacetyl chloride in 250 parts by volume of benzene is added 15 parts of solid sodium carbonate and 16.4 parts of 4-(ethylenedioxy)piperidine. The resultant mixture is refluxed for about 29 hours, left overnight at room temperature, and filtered. The filtrate is washed twice with 10% hydrochloric acid, twice with saturated sodium bicarbonate solution and once with brine. The filtrate is then dried over magnesium sulfate, concentrated and recrystallized from cyclohexane to afford 4-(ethylenedioxy)-1-(diphenylacetyl)piperidine, melting at about 136°-137° C. This compound has the following structural formula ##STR20##

1. filtrationfiltered
2. washThe filtrate is washed twice with 10% hydrochloric acid, twice with saturated sodium bicarbonate solution and once with brine
3. dry with materialThe filtrate is then dried over magnesium sulfate
4. concentrationconcentrated
5. customrecrystallized from cyclohexane