2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 53673885, compound

HRID 1449158Notes

Reaction equation

HRID 1449158 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.[CH3:17][C:18]1[CH:33]=[CH:32][CH:31]=[CH:30][C:19]=1[CH:20]=[CH:21][C:22]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)=[O:23]>C(O)CC(C)C>[CH3:17][C:18]1[CH:33]=[CH:32][CH:31]=[CH:30][C:19]=1[CH:20]=[CH:21][C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:2]2[N:11]=[C:10]([NH2:12])[C:9]3[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=3)[N:3]=2)[CH2:26][CH2:25]1)=[O:23]

Participants

4

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 54192469HCID 54192469, compound

Product 1

HCID 53673885HCID 53673885, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 479 mg. of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 461 mg. of 2-methylcinnamoylpiperazine in 10 ml. of isoamyl alcohol was heated under reflux for 4 hours. After ice-cooling, the reaction mixture was filtered and the product thus obtained was washed with ethanol to yield 812 mg. of the desired product as the hydrochloride.

Workup

  1. additionA mixture of 479 mg
  2. temperatureunder reflux for 4 hours
  3. temperatureAfter ice-cooling
  4. filtrationthe reaction mixture was filtered
  5. customthe product thus obtained
  6. washwas washed with ethanol
  7. customto yield 812 mg

Sources & evidence

ORD record
ord-acdf1dd8d99b4088b486c7ca1f7736c2
Source dataset
uspto-grants-1980_02
Patent number
US04189484

Reaction notes

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