反应详情

To a mixture of 342 mg. of 4-isopropylcinnamic acid and 727 mg. of triethylamine in 20 ml. of acetone were added dropwise under ice-cooling 195 mg. of ethyl chlorocarbonate and the resulting mixture was stirred for 3.5 hours. Then, 543 mg. of 2-(piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline.hydrochloride were added thereto and stirring was continued at room temperature overnight. Then, the acetone was distilled off, the residue was dissolved in 20 ml. of 10% K2CO3 and extracted with ethyl acetate. After drying over magnesium sulfate, the extract was concentrated and recrystallization from methanol gave 361 mg. of the desired product.

1. additionTo a mixture of 342 mg
2. temperaturecooling 195 mg
3. distillationThen, the acetone was distilled off
4. dissolutionthe residue was dissolved in 20 ml
5. extractionof 10% K2CO3 and extracted with ethyl acetate
6. dry with materialAfter drying over magnesium sulfate
7. concentrationthe extract was concentrated
8. customrecrystallization from methanol
9. customgave 361 mg