反应详情

A mixture of 479 mg. (2 mM) of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 412 mg. (2 mM) of 3-(furan-2-yl)-acryloylpiperazine in 10 ml. of isoamyl alcohol was heated under reflux for 4 hours. After ice-cooling, the crystalline substance thus separated was recovered by filtration and washed with ethanol to afford 685 mg. of the desired product as the hydrochloride.

1. additionA mixture of 479 mg
2. temperatureunder reflux for 4 hours
3. temperatureAfter ice-cooling
4. customthe crystalline substance thus separated
5. filtrationwas recovered by filtration
6. washwashed with ethanol
7. customto afford 685 mg