2-Chloro-6,7-dimethoxy-4-quinazolinamine → 2-{4-[3-(Furan-2-yl)-acryloyl]-piperazin-1-yl}-4-amino-6,7-dimethoxyquinazoline

Participants

Reaction Steps

A mixture of 479 mg. (2 mM) of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 412 mg. (2 mM) of 3-(furan-2-yl)-acryloylpiperazine in 10 ml. of isoamyl alcohol was heated under reflux for 4 hours. After ice-cooling, the crystalline substance thus separated was recovered by filtration and washed with ethanol to afford 685 mg. of the desired product as the hydrochloride.

Provenance & Evidence