Trimethyl phosphite → Dimethyl (Phthalimidomethyl)Phosphonate

HRID 1449198Notes

Reaction equation

[P:1]([O:6][CH3:7])([O:4][CH3:5])[O:2]C.BrC[CH2:10][N:11]1[C:15](=[O:16])[C:14]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]2[C:12]1=[O:21].P(OCC)(OCC)OCC>>[C:12]1(=[O:21])[N:11]([CH2:10][P:1](=[O:2])([O:6][CH3:7])[O:4][CH3:5])[C:15](=[O:16])[C:14]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]12

Participants

Reactant 3

HCID 8472Trimethyl phosphite

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

HCID 31215Triethyl phosphite

Product 1

HCID 2773790Dimethyl (Phthalimidomethyl)Phosphonate

Procedure

Reaction of N-bromoethylphthalmide with trimethyl phosphite as described in Example 18 for N-(2-bromoethyl)phthalimide and triethyl phosphite gives dimethyl phthalimidomethylphosphonate.

Sources & evidence

ORD record: ord-aa26a694030d4dd7ac740c9b5d0adf1c
Source dataset: uspto-grants-1980_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04189573

Reaction notes

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