HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Ibuprofen, (+-)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Ibuprofen, Sodium Salt | HCID 5338317 | — |
| Product | Ibuprofen, (+-)- | HCID 3672 | 93.2% |
Reaction Steps
The aqueous basic fraction containing sodium ibuprofen salt was acidified with 6N sulfuric acid, sodium chloride was added, and then extracted twice with Skellysolve B to take up the ibuprofen acid product therein. The Skellysolve B phase was dried over sodium sulfate and evaporated to leave as residue 867.7 mg. (93.2 percent yield) of ibuprofen which was 99.9 percent pure by gas liquid chromatographic (GLC) analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04189596 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-9fb0f63a25da4ea98b6394c83ae0b917 |
| Source note | uspto-grants-1980_02 |