反应详情

The mixture of 4.3 g of methyl N-(p-methylbenzyl)-o-(2,6-dichloroanilino)phenylacetate, 8 ml of benzene, 5 ml of ethanol, 8 ml of water and 2.5 g of 98% sodium hydroxide was refluxed for 8 hours under thoroughly stirring. After cooling the reaction mixture, 10% HCl aq. sol. was added to adjust pH 2 to 3 and 30 ml of ether was added and the ether phase was separated. The ether solution was dried over anhydrous sodium sulfate and the solvent was distilled off and the residue was recrystallized from ether-hexane to obtain 3.4 g of N-(p-methylbenzyl)-o-(2,6-dichloroanilino)phenylacetic acid as colorless crystals. Yield: 85%

1. temperaturewas refluxed for 8 hours
2. additionwas added
3. additionwas added
4. customthe ether phase was separated
5. dry with materialThe ether solution was dried over anhydrous sodium sulfate
6. distillationthe solvent was distilled off
7. customthe residue was recrystallized from ether-hexane