Diethyl (ethoxymethylene)malonate → HCID 12155769, compound

HRID 1449323Notes

Reaction equation

HRID 1449323 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[N:5]2.C(O[CH:15]=[C:16]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])C>>[N:8]1[C:9]2[C:4](=[CH:3][C:2]([NH:1][CH:15]=[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:11][CH:10]=2)[N:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 2378596-Quinoxalinamine

Product 1

HCID 12155769HCID 12155769, compoundYield 89.9%

Conditions

Temperature
110 °C

Procedure

A mixture of 6-aminoquinoxaline(19.2 g) and diethyl ethoxymethylenemalonate(34.8 g) was heated for an hour at 110° C. After filtration, the crystals thus obtained were crystallized from ethanol to give diethyl N-(6-quinoxalyl)aminomethylenemalonate (37.5 g) as pale yellow needles, m.p. 112°-114° C.

Workup

  1. filtrationAfter filtration
  2. customthe crystals thus obtained
  3. customwere crystallized from ethanol

Sources & evidence

ORD record
ord-0bdbed9996024388889356d8d451e9e3
Source dataset
uspto-grants-1980_02
Patent number
US04190581

Reaction notes

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