Hydrochloric Acid → HCID 54119825, compound

Participants

Reaction Steps

A mixture of ethyl 4-hydroxy-pyrazino[2,3-f]quinoline-3-carboxylate(28.8 g) and 10% potassium hydroxide solution(350 ml) was heated under reflux for an hour. The resulting reaction solution was acidified with a concentrated hydrochloric acid. After filtration, the resulting solid was washed with water and acetone, and then dried over phosphorus pentoxide to give 4-hydroxy-pyrazino[2,3-f]quinoline-3-carboxylic acid(23.5 g) as pale yellow crystalline powders, m.p. >300° C.

Provenance & Evidence