Hydrochloric Acid → HCID 54119825, compound

HRID 1449324Notes

Reaction equation

HRID 1449324 reaction equation
[OH:1][N:2]1[C:15]2[C:6](=[C:7]3[C:12](=[CH:13][CH:14]=2)[N:11]=[CH:10][CH:9]=[CH:8]3)[N:5]=[CH:4][CH:3]1[C:16]([O:18]CC)=[O:17].Cl>[OH-].[K+]>[OH:1][N:2]1[C:15]2[C:6](=[C:7]3[C:12](=[CH:13][CH:14]=2)[N:11]=[CH:10][CH:9]=[CH:8]3)[N:5]=[CH:4][CH:3]1[C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54118195HCID 54118195, compound

Product 1

HCID 54119825HCID 54119825, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

A mixture of ethyl 4-hydroxy-pyrazino[2,3-f]quinoline-3-carboxylate(28.8 g) and 10% potassium hydroxide solution(350 ml) was heated under reflux for an hour. The resulting reaction solution was acidified with a concentrated hydrochloric acid. After filtration, the resulting solid was washed with water and acetone, and then dried over phosphorus pentoxide to give 4-hydroxy-pyrazino[2,3-f]quinoline-3-carboxylic acid(23.5 g) as pale yellow crystalline powders, m.p. >300° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for an hour
  3. customThe resulting reaction solution
  4. filtrationAfter filtration
  5. washthe resulting solid was washed with water and acetone
  6. dry with materialdried over phosphorus pentoxide

Sources & evidence

ORD record
ord-5fb0b5c51aad42238c78327d71426001
Source dataset
uspto-grants-1980_02
Patent number
US04190581

Reaction notes

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