反应详情

温度

85 °C

A mixture of resorcinol (100 g, 0.908 mol), 4-chlorophenylacetic acid (170 g, 0.999 mol) and boron trifluoride etherate is stirred mechanically at 85° C. for 1.75 h. The dark red-brown reaction mixture is allowed to cool to room temperature and then poured slowly into aqueous sodium acetate (1 l, 30% w/v). The suspension is stirred overnight at room temperature. The orange brown precipitate is removed by filtration, dried in vacuo and then triturated with isopropyl ether/hexane (1:9) to give a yellow solid. This solid is washed with hexane and dried in vacuo to provide the title compound. A further three crops of material are obtained from the sodium acetate work-up mixture.

1. temperatureto cool to room temperature
2. stirringThe suspension is stirred overnight at room temperature
3. customThe orange brown precipitate is removed by filtration
4. customdried in vacuo
5. customtriturated with isopropyl ether/hexane (1:9)
6. customto give a yellow solid
7. washThis solid is washed with hexane
8. customdried in vacuo