HCID 19978307, compound → HCID 19978304, compound

HRID 1449495Notes

Reaction equation

HRID 1449495 reaction equation
C([N:9]1[CH:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH:12]2[N:11]([CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][N:25]([C:28]3[C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=4[S:30][N:29]=3)[CH2:24][CH2:23]2)[C:10]1=[O:37])(=O)C1C=CC=CC=1>O1CCOCC1.N>[S:30]1[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[C:28]([N:25]2[CH2:24][CH2:23][N:22]([CH2:21][CH2:20][CH2:19][CH2:18][N:11]3[CH:12]4[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]4[NH:9][C:10]3=[O:37])[CH2:27][CH2:26]2)=[N:29]1

Participants

4

Reactant 1

HCID 19978307HCID 19978307, compound

Product 1

HCID 19978304HCID 19978304, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

The compound (1.0 g, 1.9 mmoles) obtained in the above described paragraph (b) was dissolved in the mixed solution of 3 ml of dioxane and 3 ml of concentrated aqueous ammonia, and the resulting solution was heated in a sealed tube at 120° C. for 24 hours. The reaction was concentrated under reduced pressure, and the residue was then purified by chromatography on a silica gel column to give 0.56 g of the title compound.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe residue was then purified by chromatography on a silica gel column

Sources & evidence

ORD record
ord-d94021dba66e40f2895fd66a5ac364ef
Source dataset
uspto-grants-1997_02
Patent number
US05599815

Reaction notes

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