Hydrochloric Acid → HCID 67715287, compound

HRID 1449510Notes

Reaction equation

HRID 1449510 reaction equation
[ClH:1].[CH2:2]([C:5]1[N:9]2[CH2:10][CH2:11][CH2:12][N:13]=[C:8]2[S:7][C:6]=1[C:14]([O:16]CC)=[O:15])[CH2:3][CH3:4].Cl>[OH-].[Na+]>[ClH:1].[CH2:2]([C:5]1[N:9]2[CH2:10][CH2:11][CH2:12][N:13]=[C:8]2[S:7][C:6]=1[C:14]([OH:16])=[O:15])[CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19978166HCID 19978166, compound

Product 1

HCID 67715287HCID 67715287, compoundYield 58.9%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

In 110 ml of 1N sodium hydroxide aqueous solution was suspended 9.96 g of ethyl 3-propyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxylate hydrochloride obtained in Example 11, followed by reflux under heating for 90 minutes. After cooling, the reaction mixture was made acidic with concentrated hydrochloric acid. The precipitated crystals were collected by filtration and washed with acetone to obtain 5.3 g of the titled compound.

Workup

  1. temperatureby reflux
  2. temperatureunder heating for 90 minutes
  3. temperatureAfter cooling
  4. filtrationThe precipitated crystals were collected by filtration
  5. washwashed with acetone

Sources & evidence

ORD record
ord-70dc523fc299435ea2441f39d269c343
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

Loading…