HCID 19978264, compound → HCID 67714900, compound

HRID 1449513Notes

Reaction equation

HRID 1449513 reaction equation
[ClH:1].[CH3:2][C:3]1[N:7]2[CH2:8][CH2:9][CH2:10][N:11]=[C:6]2[S:5][C:4]=1[C:12]([O:14]C(C)(C)C)=[O:13]>Cl>[ClH:1].[CH3:2][C:3]1[N:7]2[CH2:8][CH2:9][CH2:10][N:11]=[C:6]2[S:5][C:4]=1[C:12]([OH:14])=[O:13]

Participants

3

Reactant 1

HCID 19978264HCID 19978264, compound

Product 1

HCID 67714900HCID 67714900, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In 400 ml of 2N hydrochloric acid was suspended tert-butyl 3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]-pyrimidine-2-carboxylate hydrochloride obtained in Example 26, followed by stirring at room temperature for 18 hours. The precipitated crystals were collected by filtration and washed successively with diethylether and acetone to yield 27.5 g of the titled compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed successively with diethylether and acetone

Sources & evidence

ORD record
ord-7871be5231a8449c8500bb713d609219
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

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