Sodium Hydroxide → HCID 19978176, compound

HRID 1449522Notes

Reaction equation

HRID 1449522 reaction equation
[ClH:1].[CH2:2]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]2[S:27][C:22]3=[N:23][CH2:24][CH2:25][CH2:26][N:21]3[C:20]=2[CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])=[O:18])=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[OH-].[Na+]>C(O)C>[ClH:1].[CH2:2]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]2[S:27][C:22]3=[N:23][CH2:24][CH2:25][CH2:26][N:21]3[C:20]=2[CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[O:18])=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19978168HCID 19978168, compound

Product 1

HCID 19978176HCID 19978176, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 30 ml of ethanol was dissolved 720 mg of N-(4-octylphenyl)-3-(2-ethoxycarbonylethyl)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide hydrochloride obtained in Example 79. To the solution was added 3.5 ml of 1N sodium hydroxide aqueous solution, followed by stirring at room temperature for 16 hours. The solvent was removed under reduced pressure. To the residue was added 1N hydrochloric acid to make acidic. The precipitated crystals were washed with diethylether to obtain 628 mg of the titled compound.

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionTo the residue was added 1N hydrochloric acid
  3. washThe precipitated crystals were washed with diethylether

Sources & evidence

ORD record
ord-d226e7b230f14a4db1723c6ad6795e2d
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

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