Sodium Hydroxide → HCID 19978176, compound

Participants

Reaction Steps

In 30 ml of ethanol was dissolved 720 mg of N-(4-octylphenyl)-3-(2-ethoxycarbonylethyl)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide hydrochloride obtained in Example 79. To the solution was added 3.5 ml of 1N sodium hydroxide aqueous solution, followed by stirring at room temperature for 16 hours. The solvent was removed under reduced pressure. To the residue was added 1N hydrochloric acid to make acidic. The precipitated crystals were washed with diethylether to obtain 628 mg of the titled compound.

Provenance & Evidence