HCID 19978107, compound → HCID 19978116, compound

Participants

Reaction Steps

In 50 ml of 20% hydrogenchloride aqueous solution was dissolved 360 mg of N-[3-(4-methoxycarbonylphenyl)-phenyl]-3-cyclobutyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide hydrochloride obtained in Example 105, followed by stirring under heating 9 hours. Insoluble materials were collected by filtration. The mixture was washed with water and recrystallized from methanol-ethanol to obtain 225 mg of the titled compound.

Provenance & Evidence