HCID 19978107, compound → HCID 19978116, compound

HRID 1449527Notes

Reaction equation

HRID 1449527 reaction equation
[ClH:1].C[O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19]([C:21]3[S:29][C:24]4=[N:25][CH2:26][CH2:27][CH2:28][N:23]4[C:22]=3[CH:30]3[CH2:33][CH2:32][CH2:31]3)=[O:20])[CH:15]=[CH:16][CH:17]=2)=[CH:8][CH:7]=1)=[O:5]>Cl>[ClH:1].[C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19]([C:21]3[S:29][C:24]4=[N:25][CH2:26][CH2:27][CH2:28][N:23]4[C:22]=3[CH:30]3[CH2:33][CH2:32][CH2:31]3)=[O:20])[CH:15]=[CH:16][CH:17]=2)=[CH:10][CH:11]=1)([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 19978107HCID 19978107, compound

Product 1

HCID 19978116HCID 19978116, compoundYield 64.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In 50 ml of 20% hydrogenchloride aqueous solution was dissolved 360 mg of N-[3-(4-methoxycarbonylphenyl)-phenyl]-3-cyclobutyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide hydrochloride obtained in Example 105, followed by stirring under heating 9 hours. Insoluble materials were collected by filtration. The mixture was washed with water and recrystallized from methanol-ethanol to obtain 225 mg of the titled compound.

Workup

  1. temperatureunder heating 9 hours
  2. filtrationInsoluble materials were collected by filtration
  3. washThe mixture was washed with water
  4. customrecrystallized from methanol-ethanol

Sources & evidence

ORD record
ord-cbc60156846b49c68d4b6f6795746ea8
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

Loading…