Hydrochloric Acid → HCID 9952934, compound

HRID 1449530Notes

Reaction equation

HRID 1449530 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[S:20][C:15]3=[N:16][CH2:17][CH2:18][CH2:19][N:14]3[C:13]=2[O:21][CH2:22][C:23]([O:25]CC)=[O:24])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+].Cl>C(O)C>[Cl:8][C:6]1[CH:5]=[C:4]([NH:9][C:10]([C:12]2[S:20][C:15]3=[N:16][CH2:17][CH2:18][CH2:19][N:14]3[C:13]=2[O:21][CH2:22][C:23]([OH:25])=[O:24])=[O:11])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19978109HCID 19978109, compound

Product 1

HCID 9952934HCID 9952934, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 8 ml of ethanol was suspended 650 mg of N-(3,5-dichlorophenyl)-6,7-dihydro-3-ethoxycarbonylmethoxy-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide obtained in Example 113. To the suspension was added 2 ml of 1N sodium hydroxide aqueous solution at room temperature, followed by stirring at the same temperature for 30 minutes. The mixure was made acidic with a concentrated hydrochloric acid. The precipitated crystals were collected by filtration, washed with water and diethylether, and dried to obtain 484 mg of the titled compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water and diethylether
  3. customdried

Sources & evidence

ORD record
ord-8abf5ddbb2bf4d0a9598ed16f473a26b
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

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