HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzothiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzo(b)thiophen-4-ol | HCID 19217 | — |
| Reactant | 4-(2-Bromoethyl)-5-methyl-2-phenyloxazole | HCID 15616442 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzothiophene | HCID 11232947 | 77.2% |
Reaction Steps
5.15 g (0.034 mol) 4-hydroxybenzothiophene was dissolved in 130 ml methylethylketone and admixed with 9.4 g (0.068 mol) K2CO3 and 20 g (0.068 mol) 5-methyl-2-phenyl-4-(2-bromoethyl)oxazole. The preparation was boiled for 72 hours under reflux, evaporated, taken up in ethyl acetate and extracted three times by shaking with 2N NaOH. After cooling and evaporation of the organic phase, it was crystallized from ethyl acetate/isohexane. 8.8 g 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzothiophene of melting point 130°-132° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599826 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-07a8b3b357c348039bedb8ad5344d17d |
| Source note | uspto-grants-1997_02 |