Iodoethane → HCID 44295455, compound

HRID 1449602Notes

Reaction equation

HRID 1449602 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[S:16])[NH:11][CH2:12][C:13](N)=[O:14].[CH2:17](I)[CH3:18]>>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[N:9]1[C:13](=[O:14])[CH2:12][N:11]=[C:10]1[S:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 54569709HCID 54569709, compound

Product 1

HCID 44295455HCID 44295455, compoundYield 44.3%

Procedure

The title compound was prepared by the procedure described in Example 2 using 27.8 g of 2-[3-(2,6-dichlorophenyl)-thioureido]-acetamide and 31.2 g of ethyl iodide. 12.8 g of the title compound was obtained, m.p. 122°-124° C. Anal. Calcd. for. C11H10Cl2N2O S: C, 45.69; H, 3.49; N, 9.69. Found: C, 45.62; H, 3.33; N, 9.43. Mass spectrum (+FAB, [M+H]+) m/z 289/291/293. 1H-NMR (DMSO-d6 ; 400 MHz) δ7.72 (s, 1H), 7.70 (s, 1H), 7.58 (t, 1H), 4.50 (s, 2H), 3.10 (q, 2H), and 1.27 ppm (t, 3H).

Workup

  1. customThe title compound was prepared by the procedure

Sources & evidence

ORD record
ord-1acf68315a4d4559aa7e6751efcef37e
Source dataset
uspto-grants-1997_02
Patent number
US05599829

Reaction notes

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