1-Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazine → 1-[3-(1,1-Dimethylethylamino)pyridyl]piperazine

HRID 1449745Notes

Reaction equation

HRID 1449745 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([NH:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:24][C:21]([NH:20][C:19]1[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:15][CH:16]=[CH:17][CH:18]=1)([CH3:22])[CH3:23]

Participants

5

Reactant 2

HCID 214776231-Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 110426831-[3-(1,1-Dimethylethylamino)pyridyl]piperazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1- Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazine (PREPARATION 96, 4.25 g, 13.10 mmol) is dissolved in 100 ml ethanol. Palladium (10% on carbon, 1.0 g) is added and the solution hydrogenated at 40 psi hydrogen gas. The mixture is filtered and concentrated to give the title compound, NMR (300 MHz, CD3OD) 7.53, 7.19, 6.93, 2.95, 1.39 δ.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-f87236048290426e8144f2d1fdb4d147
Source dataset
uspto-grants-1997_02
Patent number
US05599930

Reaction notes

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