Tetrahydrofuran → HCID 23352645, 화합물

HRID 1449826노트

반응식

HRID 1449826 반응식
O1CCCC1.[S:6]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][O:13][C:14](=[O:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]Br)=[CH:7]1.[NH2:22][CH2:23][CH:24]([C:26]1[CH:31]=[C:30]([Cl:32])[C:29]([NH2:33])=[C:28]([Cl:34])[CH:27]=1)[OH:25]>C(OCC)(=O)C.C(N(CC)CC)C>[S:6]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][O:13][C:14](=[O:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:22][CH2:23][CH:24]([C:26]2[CH:27]=[C:28]([Cl:34])[C:29]([NH2:33])=[C:30]([Cl:32])[CH:31]=2)[OH:25])=[CH:7]1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 217242Benzenemethanol, 4-amino-alpha-(aminomethyl)-3,5-dichloro-HCID 53734924HCID 53734924, 화합물

생성물 1

HCID 23352645HCID 23352645, 화합물

시약·촉매·용매 1

HCID 22036596Ethyl acetate triethylamine용매

실험 절차

According to method I (tetrahydrofuran, reflux 4 days) from {2-(3-thienyl)ethyl}6-bromohexanoate and 2-amino-1-(4-amino-3,5-dichlorophenyl)ethanol. Working up by means of chromatography (ethyl acetate/triethylamine 8:1). Recrystallized as the base from diethyl ether. Melting point: 71°-73° C.

후처리

  1. customRecrystallized as the base from diethyl ether

출처 및 근거

ORD 기록
ord-5bfcc93f4d0a4a3fabd518a853bb4568
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05599966

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