HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-(3-Thienyl)ethyl6-[2-(4-amino-3,5-dichlorophenyl)-2-hydroxyethylamino]hexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzenemethanol, 4-amino-alpha-(aminomethyl)-3,5-dichloro- | HCID 217242 | — |
| Reactant | HCID 53734924 | HCID 53734924 | — |
| Solvent | Ethyl acetate triethylamine | HCID 22036596 | — |
| Product | 2-(3-Thienyl)ethyl6-[2-(4-amino-3,5-dichlorophenyl)-2-hydroxyethylamino]hexanoate | HCID 23352645 | — |
Reaction Steps
According to method I (tetrahydrofuran, reflux 4 days) from {2-(3-thienyl)ethyl}6-bromohexanoate and 2-amino-1-(4-amino-3,5-dichlorophenyl)ethanol. Working up by means of chromatography (ethyl acetate/triethylamine 8:1). Recrystallized as the base from diethyl ether. Melting point: 71°-73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599966 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-5bfcc93f4d0a4a3fabd518a853bb4568 |
| Source note | uspto-grants-1997_02 |