Dimethylformamide → HCID 23352667, compound

HRID 1449827Notes

Reaction equation

HRID 1449827 reaction equation
CN(C)C=O.[O:6]([CH2:13][CH2:14][O:15][C:16](=[O:23])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]Br)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:24][CH2:25][CH:26]([C:28]1[CH:33]=[C:32]([Cl:34])[C:31]([NH2:35])=[C:30]([Cl:36])[CH:29]=1)[OH:27]>C(OCC)(=O)C.CO.C(N(CC)CC)C>[O:6]([CH2:13][CH2:14][O:15][C:16](=[O:23])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:24][CH2:25][CH:26]([C:28]1[CH:29]=[C:30]([Cl:36])[C:31]([NH2:35])=[C:32]([Cl:34])[CH:33]=1)[OH:27])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 217242Benzenemethanol, 4-amino-alpha-(aminomethyl)-3,5-dichloro-HCID 53926445HCID 53926445, compound

Product 1

HCID 23352667HCID 23352667, compound

Reagents, catalysts & solvents 1

HCID 21980445Ethyl acetate methanol triethylamineSolvent

Procedure

According to method I (dimethylformamide, 1 hour at 100° C.) from (2-phenoxyethyl)6-bromohexanoate and 2-amino-1-(4-amino-3,5-dichlorophenyl)ethanol. Working up by means of chromatography (ethyl acetate/methanol/triethylamine 16:2:1). Recrystallized as the base from diethyl ether. Melting point: 46°-47° C.

Workup

  1. customRecrystallized as the base from diethyl ether

Sources & evidence

ORD record
ord-3ef03dda523b43cd84b9526f2ac95acc
Source dataset
uspto-grants-1997_02
Patent number
US05599966

Reaction notes

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