反应详情

Add methanesulfonic acid (47.7 kg, 496 mol) to a toluene solution of ethyl 2-(difluoromethyl)-2-(t-butoxycarbonyl)-4-(p-fluorophenyl)butyrate as prepared in Example 3.1 at a temperature of 40° C.-50° C. After 3 to 6 hours, cool the reaction to ambient temperature. Add toluene (91 kg) and water (421 kg) and stir for 30 minutes. Separate the aqueous layer. Add to the organic layer a 20% by weight solution of sodium chloride in water (420 kg) and stir for 30 minutes. Separate the layers to give the title compound as a solution in toluene.

1. customas prepared in Example 3.1 at a temperature of 40° C.-50° C
2. temperaturecool
3. customthe reaction to ambient temperature
4. customSeparate the aqueous layer
5. additionAdd to the organic layer a 20% by weight solution of sodium chloride in water (420 kg)
6. customSeparate the layers